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Elderly sometimes keep using opioids after surgery
Mar 15, 12 Drug NewsOne in ten older adults prescribed a powerful painkiller after surgery was still filling prescriptions for the drug a year later, a new study from Canada shows.
Because so-called opioids, which include codeine and OxyContin, have a higher risk of abuse and overdose than other painkillers, researchers say the drugs should be prescribed carefully and patients followed closely.
The patients in the current study hadn’t taken opioids before their surgeries, and all of the procedures were considered low-pain.
“You’re sort of introducing something which was originally intended for a very transient event, and even that transient event might not have required codeine,” said Dr. Chaim Bell from St. Michael’s Hospital in Toronto, who worked on the study.
Bell’s team found that out of close to 400,000 patients age 66 years and older who had short-stay surgery in Ontario between 1997 and 2008, about seven percent were prescribed an opioid—most commonly codeine - within a week of being discharged from the hospital.
Those procedures included cataract surgery, gallbladder or prostate tissue removal and varicose vein stripping.
A year later, one out of every ten patients initially prescribed the painkillers was still taking opioids. On average, those longer-term users had filled prescriptions for 33 pills during the year, and some were taking stronger opioids than they’d first been prescribed.
Among 391 139 opioid-naive patients undergoing short-stay surgery, opioids were newly prescribed to 27 636 patients (7.1%) within 7 days of being discharged from the hospital, and opioids were prescribed to 30 145 patients (7.7%) at 1 year from surgery. An increase in the use of oxycodone was found during this time (from 5.4% within 7 days to 15.9% at 1 year). In our primary analysis, patients receiving an opioid prescription within 7 days of surgery were 44% more likely to become long-term opioid users within 1 year compared with those who received no such prescription (adjusted odds ratio, 1.44; 95% CI, 1.39-1.50). In a secondary analysis, among 383 780 NSAID-naive patients undergoing short-stay surgery, NSAIDs were prescribed to 1169 patients (0.3%) within 7 days of discharge and to 30 080 patients (7.8%) at 1 year from surgery. Patients who began taking NSAIDs within 7 days of surgery were almost 4 times more likely to become long-term NSAID users compared with patients with no such prescription (adjusted odds ratio, 3.74; 95% CI, 3.27-4.28).Patients who were prescribed post-surgery opioids were 44 percent more likely to be taking them a year later than those whose doctors didn’t initially prescribe the drugs, Bell’s team reported on Monday in the Archives of Internal Medicine.
The researchers didn’t have notes on why each patient was prescribed painkillers, so they couldn’t tell if the older adults were still treating surgery-related pain a year later, or if they had a new injury or illness in the interim.
Still, the findings suggest that surgeons should reconsider prescribing opioids to patients who haven’t had high-pain surgery because of longer-term risks, researchers said.
“It’s much easier to stop something’s initiation rather than weaning someone off it afterwards,” Bell told Reuters Health.
He said surgeons typically have a generic post-surgery form for all patients that gives them the option to prescribe powerful painkillers—but maybe that choice isn’t needed and shouldn’t even be offered after low-pain surgeries, according to Bell.
When patients do really need opioids, he said, there should be better communication between the prescribing surgeon, the patient and that patient’s primary care doctor about whether they’ll need any drug refills and what to expect from the recovery process.
Patients themselves, he added, can ask their surgeons: “How long do I need to be on these for? When should the pain go away?”
It may be especially important to think twice about opioids in elderly patients, said Dr. Daniel Solomon, who has studied effects of the drugs at Harvard Medical School in Boston.
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