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CeeNU lomustine - Bristol-Myers Squibb
CeeNU: Black Box Warnings
Appropriate Use
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admin. only under supervision of physician experienced in cancer chemotx
Myelosuppression
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most common, severe toxicity is delayed myelosuppression, primarily
thrombocytopenia and leukopenia; monitor CBC qwk x6wk, adjust dose per
pkg insert; space courses at least 6wk apart
CeeNU: Adult Dosing
Dosage forms: 10,40,100chemotherapy
- uses, dosing may vary
- Info: for all uses, refer to institution protocols and pkg insert prior to prescribing; see pkg insert for toxicity-related dose adjustments
brain tumors, primary and metastatic
- 130 mg/m^2 PO x1 q6wk
- Info: give 100 mg/m^2 PO x1 q6wk if compromised bone marrow function; see pkg insert for hematologic toxicity-related dose adjustments; doses may differ when used in combo regimens
Hodgkin's lymphoma
- 130 mg/m^2 PO x1 q6wk
- Info: give 100 mg/m^2 PO x1 q6wk if compromised bone marrow function; see pkg insert for hematologic toxicity-related dose adjustments; doses may differ when used in combo regimens
renal dosing
- adjust dose amount
- CrCl 10-50: decr. dose 25%; CrCl <10: decr. dose 50-75%; HD/CAPD: no supplement
hepatic dosing
- not defined
CeeNU: Peds Dosing
Dosage forms: 10,40,100chemotherapy
- uses, dosing may vary
- Info: for all uses, refer to institution protocols and pkg insert prior to prescribing; see pkg insert for toxicity-related dose adjustments
brain tumors, primary and metastatic
- 130 mg/m^2 PO x1 q6wk
- Info: give 100 mg/m^2 PO x1 q6wk if compromised bone marrow function; see pkg insert for hematologic toxicity-related dose adjustments; doses may differ when used in combo regimens
Hodgkin's lymphoma
- 130 mg/m^2 PO x1 q6wk
- Info: give 100 mg/m^2 PO x1 q6wk if compromised bone marrow function; see pkg insert for hematologic toxicity-related dose adjustments; doses may differ when used in combo regimens
renal dosing
- adjust dose amount
- CrCl 10-50: decr. dose 25%; CrCl <10: decr. dose 50-75%; HD/CAPD: no supplement
hepatic dosing
- not defined
CeeNU: Contraindications/Cautions
- hypersens. to drug/class/compon.
- caution if myelosuppression
CeeNU: Drug Interactions
Contraindicated
Avoid/Use Alternative
Monitor/Modify Tx
Caution Advised
CeeNU: Adverse Reactions
Serious Reactions
- myelosuppression, delayed
- thrombocytopenia
- leukopenia
- anemia
- bone marrow dysplasia
- secondary malignancy
- leukemia
- pulmonary infiltrates (rare)
- pulmonary fibrosis (rare)
- hepatotoxicity
- azotemia, progressive
- renal failure
- stomatitis
- optic atrophy
- blindness
- ataxia
Common Reactions
- myelosuppression
- thrombocytopenia
- leukopenia
- nausea/vomiting
- loss of appetite
- alopecia
- confusion
- lethargy
- dysarthria
- decr. kidney size
CeeNU: Safety Monitoring
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Pregnancy:
D
- Lactation:
Unsafe
- Monitoring Parameters:
PFTs at baseline, then frequently during tx; CBC w/ diff, Plt qwk x 6wk; BUN/Cr; LFTs
CeeNU: Pharmacology
- Metabolism: liver; CYP450: unknown; Info: active metabolites
- Excretion: urine (50%); Half-life: 16-48h (metabolites)
- Class:
Alkylating Agents
- Mechanism Of Action
alkylates and crosslinks DNA (nitrosourea)CeeNU: Manufacturer/Pricing
- Manufacturer:
Bristol-Myers Squibb Co.
- DEA/FDA: Rx
CeeNU: Patient Education
Patient education material for this drug is not currently available.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
CeeNU: Pill Pictures
This information is currently unavailable or not applicable for this drug.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you. You should consult your healthcare professional before taking any drug, changing your diet or commencing or discontinuing any course of treatment.
Substantial effort has been made to ensure that the information provided by Rx Drug News is accurate and up-to-date, but this information is not intended to cover all possible uses, precautions, or other considerations relating to the therapies covered.
Rx Drug News does not advocate or endorse the use of any drug or other therapy and does not diagnose patients.
Healthcare professionals should use their professional judgment in using this information, and this information should not be considered a substitute for the care and professional judgment provided by a licensed healthcare practitioner.
This information if provided on an "as is" basis, and Rx Drug News and its affiliates, agents and licensors assume no responsibility for any aspect of healthcare administered with the aid of this information or any other use of the information.
Copyright 1996-2006 Cerner Multum, Inc. Version: 5.05. Revision Date: 10/09/2007
Last Updated: 10/09/2007
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